[HTML][HTML] Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
DunedinPACE, a DNA methylation biomarker of the pace of aging
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
[HTML][HTML] Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …
ageing. A number of measures of biological age have been proposed which harness age …
[HTML][HTML] Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
[HTML][HTML] DNA methylation GrimAge strongly predicts lifespan and healthspan
AT Lu, A Quach, JG Wilson, AP Reiner, A Aviv… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …
[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death
Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge
Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …
epidemiology and population science and have been proposed as surrogate measures for …
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …
predictors of health outcomes and mortality in older populations. However, it is unknown …
[HTML][HTML] Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging …
O Demidenko, D Barardo, V Budovskii… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The search continues for possible interventions that delay and/or reverse biological aging,
resulting in extended healthspan and lifespan. Interventions delaying aging in animal …
resulting in extended healthspan and lifespan. Interventions delaying aging in animal …
[HTML][HTML] Simplified assay for epigenetic age estimation in whole blood of adults
L Vidal-Bralo, Y Lopez-Golan, A Gonzalez - Frontiers in genetics, 2016 - frontiersin.org
Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …
interest for understanding how diseases and environmental insults affect tissue function …