Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

[HTML][HTML] Astrocytes: a double-edged sword in neurodegenerative diseases

ZB Ding, LJ Song, Q Wang, G Kumar… - Neural regeneration …, 2021 - journals.lww.com
Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the
central nervous system by regulating homeostasis, increasing synaptic plasticity, and …

Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Reactive astrocytes as drug target in Alzheimer's disease

BT Assefa, AK Gebre, BM Altaye - BioMed research …, 2018 - Wiley Online Library
Alzheimer's disease is a neurodegenerative disease characterized by deposition of
extracellular amyloid‐β, intracellular neurofibrillary tangles, and loss of cortical neurons …

Amyloid-β and astrocytes interplay in amyloid-β related disorders

YS Batarseh, QV Duong, YM Mousa… - International journal of …, 2016 - mdpi.com
Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain.
It was thought previously that Aβ is only associated with Alzheimer's disease and Down …

Functions of astrocytes under normal conditions and after a brain disease

SL Valles, SK Singh, J Campos-Campos… - International Journal of …, 2023 - mdpi.com
In the central nervous system (CNS) there are a greater number of glial cells than neurons
(between five and ten times more). Furthermore, they have a greater number of functions …

The contribution of astrocytes to Alzheimer's disease

AM Birch - Biochemical Society Transactions, 2014 - portlandpress.com
Astrocytes were historically classified as supporting cells; however, it is becoming
increasingly clear that they actively contribute to neuronal functioning under normal and …

Astrocytes: role and functions in brain pathologies

R Siracusa, R Fusco, S Cuzzocrea - Frontiers in Pharmacology, 2019 - frontiersin.org
Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …

Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

MS Uddin, LW Lim - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Pathological phenotypes of astrocytes in Alzheimer's disease

J Kim, ID Yoo, J Lim, JS Moon - Experimental & Molecular Medicine, 2024 - nature.com
Astrocytes are involved in various processes in the central nervous system (CNS). As the
most abundant cell type in the CNS, astrocytes play an essential role in neuronal …