The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Age is the greatest risk factor for nearly every major cause of mortality in developed nations.
Despite this, most biomedical research focuses on individual disease processes without …

Among individuals, biological aging leads to cellular and organismal dysfunction and an
increased risk of chronic degenerative diseases and disability. This sequence of events in …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …