From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …

Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …

The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …

Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and
specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

Immunosenescence is the term commonly used to describe the multifaceted phenomenon
encompassing all changes occurring in the immune system during aging. It contributes to …

Immunosenescence is a multi-faceted phenomenon at the root of age-associated immune
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …

Deterioration of the immune system with aging (" immunosenescence") is believed to
contribute to morbidity and mortality in man due to the greater incidence of infection, as well …

Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …