The alteration of DNA methylation patterns are a key component of disease onset and/or
progression. Our objective was to evaluate the differences in Long Interspersed Nuclear …

Introduction Multiple Sclerosis (MS) has a complex pathophysiology that involves genetic
and environmental factors. DNA methylation (DNAm) is one epigenetic mechanism that can …

The combination of genetic and epigenetic influences alters the development of complex
diseases. Aberrant patterns of DNA methylation are associated with inflammation and …

Multiple sclerosis (MS) is an autoimmune, neurological disease. We investigated genome-
wide DNA methylation profiles of CD4+ and CD8+ T cells from MS patients and healthy …

One of the major challenges in multiple sclerosis (MS) is to accurately monitor and quantify
disability over time. Thus, there is a pressing need to identify new biomarkers for disease …

Abstract Background Multiple Sclerosis (MS) is a chronic inflammatory disease and a
leading cause of progressive neurological disability among young adults. DNA methylation …

Concentrations of cell-free DNA (cfDNA) circulating in blood and its epigenetic variation,
such as DNA methylation, may provide useful diagnostic or prognostic information. Long …

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous
system characterised by incoordination, sensory loss, weakness, changes in bladder …

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of
the central nervous system that involves several not yet fully elucidated pathophysiologic …

Epigenetic mechanisms can regulate how DNA is expressed independently of sequence
and are known to be associated with various diseases. Among those epigenetic …