Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Abstract Social Signal Transduction Theory of Depression is a biologically plausible, multi-
level theory that describes neural, physiologic, molecular, and genomic mechanisms that …

Consistent evidence links major depression and its affective components to negative health
outcomes. Although the pathways of these effects are likely complex and multifactorial …

A wealth of evidence has implicated inflammation in the development of depression. Yet, the
heterogeneous nature of depression has impeded efforts to understand, prevent, and treat …

Increasing amounts of data suggest that inflammatory responses have an important role in
the pathophysiology of depression. Depressed patients have been found to have higher …

Activation of the inflammatory immune system provokes numerous neuroendocrine and
neurotransmitter changes, many of which are similar to those provoked by physical or …

Psychosocial stress is capable of causing immune dysregulation and increased
neuroinflammatory signaling by repeated activation of the neuroendocrine and autonomic …

Depression is among the most significant public mental health issues. A growing body of
research implicates inflammation in the etiology and pathophysiology of depression. Yet, the …

Depression represents a major public health problem. It is estimated that 13–20% of the
population has some depressive symptoms at any given time and about 5% of the …

Recognition that inflammation may represent a common mechanism of disease has been
extended to include neuropsychiatric disorders including major depression. Patients with …