Circulating tumor DNA minimal residual disease detection of non–small-cell lung cancer treated with curative intent

B Pellini, AA Chaudhuri - Journal of Clinical Oncology, 2022 - ascopubs.org
Circulating tumor DNA (ctDNA) minimal residual disease (MRD) is a powerful biomarker
with the potential to improve survival outcomes for non–small-cell lung cancer (NSCLC) …

[HTML][HTML] Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

S Wang, M Li, J Zhang, P Xing, M Wu, F Meng… - Journal of hematology & …, 2022 - Springer
Abstract Background Circulating tumor DNA (ctDNA) has been proven as a marker for
detecting minimal residual diseases following systemic therapies in mid-to-late-stage non …

Early assessment of circulating tumor DNA after curative‐intent resection predicts tumor recurrence in early‐stage and locally advanced non‐small‐cell lung cancer

S Waldeck, J Mitschke, S Wiesemann… - Molecular …, 2022 - Wiley Online Library
Circulating tumor DNA (ctDNA) has demonstrated great potential as a noninvasive
biomarker to assess minimal residual disease (MRD) and profile tumor genotypes in …

[HTML][HTML] Detection of minimal residual disease using ctDNA in lung cancer: current evidence and future directions

YK Chae, MS Oh - Journal of thoracic oncology, 2019 - Elsevier
Advances in DNA sequencing methods have significantly expanded the potential clinical
applications of analyzing circulating tumor DNA (ctDNA). This genetic information can …

Early stage NSCLC—challenges to implementing ctDNA-based screening and MRD detection

C Abbosh, NJ Birkbak, C Swanton - Nature Reviews Clinical Oncology, 2018 - nature.com
Circulating tumour DNA (ctDNA) refers to the fraction of cell-free DNA in a patient's blood
that originates from a tumour. Advances in DNA sequencing technologies and our …

Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling

AA Chaudhuri, JJ Chabon, AF Lovejoy, AM Newman… - Cancer discovery, 2017 - AACR
Identifying molecular residual disease (MRD) after treatment of localized lung cancer could
facilitate early intervention and personalization of adjuvant therapies. Here, we apply cancer …

[HTML][HTML] Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer

D Gale, K Heider, A Ruiz-Valdepenas, S Hackinger… - Annals of oncology, 2022 - Elsevier
Background Identification of residual disease in patients with localized non-small cell lung
cancer (NSCLC) following treatment with curative intent holds promise to identify patients at …

[HTML][HTML] Circulating tumor DNA and minimal residual disease (MRD) in solid tumors: current horizons and future perspectives

Y Peng, W Mei, K Ma, C Zeng - Frontiers in oncology, 2021 - frontiersin.org
Circulating tumor DNA (ctDNA) is cell-free DNA (cfDNA) fragment in the bloodstream that
originates from malignant tumors or circulating tumor cells. Recently, ctDNA has emerged as …

[HTML][HTML] Circulating tumor DNA as a prognostic biomarker in localized non-small cell lung cancer

M Peng, Q Huang, W Yin, S Tan, C Chen, W Liu… - Frontiers in …, 2020 - frontiersin.org
Background Routine clinical surveillance involves serial radiographic imaging following
radical surgery in localized non-small cell lung cancer (NSCLC). However, such …

Abstract CT023: Phylogenetic tracking and minimal residual disease detection using ctDNA in early-stage NSCLC: A lung TRACERx study

C Abbosh, A Frankell, A Garnett, T Harrison… - Cancer Research, 2020 - AACR
Introduction Minimal residual disease (MRD) detection in solid tumors describes isolation of
circulating tumor DNA (ctDNA) molecules in plasma following definitive treatment of a …