[HTML][HTML] Development of the amorphous solid dispersion of curcumin: a rational selection of polymers for enhanced solubility and dissolution

M Ishtiaq, S Asghar, IU Khan, MS Iqbal, SH Khalid - Crystals, 2022 - mdpi.com
The goal of this investigation was to determine the effectiveness of hydrophilic polymers in
preparing a solid dispersion to enhance the solubility and dissolution of poorly water-soluble …

[HTML][HTML] Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties

S Zong, Y Liu, HJ Park, M Ye, J Li - Brazilian Journal of …, 2022 - SciELO Brasil
To investigate structure–property relationship of polymer-based curcumin solid dispersion
(SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation …

Advantages of introducing an effective crystalline inhibitor in curcumin amorphous solid dispersions formulated by Eudragit E100

N Fan, J Li, J Li - Journal of Pharmacy and Pharmacology, 2021 - academic.oup.com
Objectives This paper was to elucidate the advantages of using an effective crystalline
inhibitor, which was hydroxypropyl methylcellulose E5 (HPMC), in inhibiting crystallisation …

Enhancement of Curcumin Solubility Using a Novel Solubilizing Polymer Soluplus®

F Al-Akayleh, I Al-Naji, S Adwan, M Al-Remawi… - Journal of …, 2020 - Springer
Purpose In this study, a novel solubility enhancement excipient (Soluplus®) was
investigated to improve the solubility and dissolution rate of Curcumin, a poorly water …

[PDF][PDF] Characterization and evaluation of curcumin-PVP Solid dispersion by solvent evaporation technique

SD Kumavat, YS Chaudhari, P Borole… - Int J Pharm Res …, 2013 - academia.edu
Curcumin, a naturally occurring highly lipophilic molecule has wide range of
pharmacological activities. However, its limited aqueous solubility and degradation at …

Development and characterization of an amorphous curcumin-Eudragit®E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties

X Wang, Y Zhu, X Zhao, S Zhang, M Cao… - Pharmaceutical …, 2022 - Taylor & Francis
The development of amorphous solid dispersions (ASD) is one way to overcome the
bioavailability challenges of poorly water-soluble drug. Herein, Curcumin (CUR) was …

Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier

SW Seo, HK Han, MK Chun, HK Choi - International journal of …, 2012 - Elsevier
Solubility of curcumin at physiological pH was significantly increased by forming solid
dispersion (SD) with Solutol® HS15. Since curcumin undergoes hydrolytic degradation …

Enhancement of oral bioavailability of curcumin by a novel solid dispersion system

L Hu, Y Shi, JH Li, N Gao, J Ji, F Niu, Q Chen, X Yang… - Aaps Pharmscitech, 2015 - Springer
The objective of this study was to improve the solubility and bioavailability of curcumin by a
new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal …

Curcumin amorphous solid dispersions: the influence of intra and intermolecular bonding on physical stability

LA Wegiel, Y Zhao, LJ Mauer, KJ Edgar… - Pharmaceutical …, 2014 - Taylor & Francis
We have investigated the physical stability of amorphous curcumin dispersions and the role
of curcumin–polymer intermolecular interactions in delaying crystallization. Curcumin is an …

Characterization of curcumin–PVP solid dispersion obtained by spray drying

A Paradkar, AA Ambike, BK Jadhav… - International journal of …, 2004 - Elsevier
Curcumin, a naturally occurring highly lipophilic molecule has wide range of
pharmacological activities. However, its limited aqueous solubility and degradation at …