Ageing is accompanied by important chemical deregulations resulting in bodily metal
imbalances. The way and extent to which these deregulations are associated with ageing …

Many late-onset proteotoxic diseases are accompanied by a disruption in homeostasis of
metals (metallostasis) including iron, copper and zinc. Although aging is the most prominent …

Organic elements make up 99% of an organism but without the remaining inorganic
bioessential elements, termed the metallome, no life could be possible. The metallome is …

Copper (Cu) stable isotopes are useful for understanding pathways and tracing changes in
Cu homeostasis, such as those induced by various diseases (eg liver cirrhosis, numerous …

The model species, Caenorhabditis elegans, has been used as a tool to probe for
mechanisms underlying numerous neurodegenerative diseases. This use has been …

Zinc is an essential trace metal that has integral roles in numerous biological processes,
including enzymatic function, protein structure, and cell signaling pathways. Both excess …

Scope Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also
potential exogenous risk factors for various diseases. Since the disturbed homeostasis of …

Parkinson's disease (PD) is a debilitating motor and cognitive neurodegenerative disorder
for which there is no cure. While aging is the major risk factor for developing PD, clear …

Metals are essential in biochemistry, with highly regulated localisation and concentration. To
continue elucidating the impact of inorganic physiology on cellular process in health and …

Iron is essential for eukaryotic biochemistry. Systematic trafficking and storage is required to
maintain supply of iron while preventing it from catalysing unwanted reactions, particularly …