Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers

HM Dunnenberger, KR Crews… - Annual review of …, 2015 - annualreviews.org
Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …

Preemptive panel-based pharmacogenetic testing: the time is now

KW Weitzel, LH Cavallari, LJ Lesko - Pharmaceutical research, 2017 - Springer
While recent discoveries have paved the way for the use of genotype-guided prescribing in
some clinical environments, significant debate persists among clinicians and researchers …

Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping

JS Schildcrout, JC Denny, E Bowton… - Clinical …, 2012 - Wiley Online Library
Routine integration of genotype data into drug decision making could improve patient safety,
particularly if many relevant genetic variants can be assayed simultaneously before …

[HTML][HTML] Advancing pharmacogenomics from single-gene to preemptive testing

CE Haidar, KR Crews, JM Hoffman… - Annual review of …, 2022 - annualreviews.org
Pharmacogenomic testing can be an effective tool to enhance medication safety and
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …

Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing

SL Van Driest, Y Shi, EA Bowton… - Clinical …, 2014 - Wiley Online Library
Since September 2010, more than 10,000 patients have undergone preemptive, panel‐
based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for …

Benefit of preemptive pharmacogenetic information on clinical outcome

DM Roden, SL Van Driest, JD Mosley… - Clinical …, 2018 - Wiley Online Library
The development of new knowledge around the genetic determinants of variable drug action
has naturally raised the question of how this new knowledge can be used to improve the …

Development of the PG x‐Passport: a panel of actionable germline genetic variants for pre‐emptive pharmacogenetic testing

CH van der Wouden, MH van Rhenen… - Clinical …, 2019 - Wiley Online Library
Pre‐emptive pharmacogenetics (PG x) testing of a panel of germline genetic variants
represents a new model for personalized medicine. Clinical impact of PG x testing is …

[HTML][HTML] Preemptive pharmacogenetic testing: exploring the knowledge and perspectives of US payers

NJ Keeling, MM Rosenthal, D West-Strum, AS Patel… - Genetics in …, 2019 - Elsevier
Purpose Preemptive pharmacogenetic testing aims to optimize medication use by having
genetic information at the point of prescribing. Payers' decisions influence implementation of …

Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time—using genomic data to individualize treatment protocol

SJ Bielinski, JE Olson, J Pathak… - Mayo Clinic …, 2014 - Elsevier
Objective To report the design and implementation of the Right Drug, Right Dose, Right
Time—Using Genomic Data to Individualize Treatment protocol that was developed to test …

Adoption of a clinical pharmacogenomics implementation program during outpatient care–initial results of the University of Chicago “1,200 Patients Project”

PH O'Donnell, K Danahey, M Jacobs… - American Journal of …, 2014 - Wiley Online Library
Pharmacogenomic testing is viewed as an integral part of precision medicine. To achieve
this, we originated The 1,200 Patients Project which offers broad, preemptive …