Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Advancing age is the major risk factor for the development of chronic diseases and is
accompanied by changes in metabolic processes and mitochondrial dysfunction …

The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major
aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive …

The sirtuins are a family of proteins that act predominantly as nicotinamide adenine
dinucleotide (NAD)-dependent deacetylases. In mammals seven sirtuin family members …

Despite recent controversy about their function in some organisms, sirtuins are thought to
play evolutionarily conserved roles in lifespan extension. Whether sirtuins can reverse aging …

The sirtuins are a group of proteins linked to aging, metabolism and stress tolerance in
several organisms. Among the many genes that have been shown to affect aging in model …

The energy production and metabolic homeostasis are well-orchestrated networks of
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …

Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin
research has focused on SirT1, which deacetylates transcription factors and cofactors in the …

Sirtuins comprise a family of nicotinamide adenine dinucleotide (NAD+)-dependent lysine
deacylases that regulate the life span, aging, and metabolism. Seven sirtuin family members …

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of
mammalian class III histone deacetylases heavily implicated in health span and longevity …