Generation and characterization of a humanized ACE2 mouse model to study long‐term impacts of SARS‐CoV‐2 infection

CY Choi, K Gadhave, J Villano… - Journal of Medical …, 2024 - Wiley Online Library
Although the COVID‐19 pandemic has officially ended, the persistent challenge of long‐
COVID or post‐acute COVID sequelae (PASC) continues to impact societies globally …

SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice

ES Winkler, RE Chen, F Alam, S Yildiz, JB Case… - Journal of …, 2022 - Am Soc Microbiol
The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus

W Dong, H Mead, L Tian, JG Park, JI Garcia… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …

[HTML][HTML] Rapidly deployable mouse models of SARS-CoV-2 infection add flexibility to the COVID-19 toolbox

JA Harker, C Johansson - American Journal of Respiratory Cell and …, 2021 - atsjournals.org
The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
continues to progress quickly, with over 36 million people infected and over 1 million deaths …

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

ES Winkler, AL Bailey, NM Kafai, S Nair, BT McCune… - BioRxiv, 2020 - biorxiv.org
ABSTRACT Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged in
late 2019 and has spread worldwide resulting in the Coronavirus Disease 2019 (COVID-19) …

Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection

IW Song, M Washington, C Leynes, J Hsu… - Mammalian …, 2024 - Springer
Abstract The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) remains a
public health concern and a subject of active research effort. Development of pre-clinical …

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF-and IFNγ-driven immunopathology

R Gawish, P Starkl, L Pimenov, A Hladik, K Lakovits… - Elife, 2022 - elifesciences.org
Despite tremendous progress in the understanding of COVID-19, mechanistic insight into
immunological, disease-driving factors remains limited. We generated maVie16, a mouse …

[HTML][HTML] A mouse model of SARS-CoV-2 infection and pathogenesis

SH Sun, Q Chen, HJ Gu, G Yang, YX Wang… - Cell host & …, 2020 - cell.com
Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

A lethal mouse model using a mouse-adapted SARS-CoV-2 strain with enhanced binding to mouse ACE2 as an important platform for COVID-19 research

H Chu, JFW Chan - EBioMedicine, 2021 - thelancet.com
Since its discovery in December 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused over 146 million cases of Coronavirus Disease 2019 (COVID …

A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection

L Hassler, J Wysocki, I Gelarden, A Tomatsidou, H Gula… - BioRxiv, 2021 - biorxiv.org
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length
angiotensin converting enzyme 2 (ACE2), which is membrane bound, as its initial cell …