Nicotinic receptor subunits atlas in the adult human lung

Z Diabasana, JM Perotin, R Belgacemi, J Ancel… - International Journal of …, 2020 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
responsible for rapid neural and neuromuscular signal transmission. Although it is well …

Neuronal acetylcholine nicotinic receptors as new targets for lung cancer treatment

V Mucchietto, A Crespi, F Fasoli… - Current …, 2016 - ingentaconnect.com
Lung cancer is the leading cause of cancer-related deaths worldwide. Smoking accounts for
approximately 70% of the cases of non–small cell lung cancer (NSCLC) and 90% of the …

Nicotinic acetylcholine receptors in the respiratory tract

MI Hollenhorst, G Krasteva-Christ - Molecules, 2021 - mdpi.com
Nicotinic acetylcholine receptors (nAChR) are widely distributed in neuronal and non-
neuronal tissues, where they play diverse physiological roles. In this review, we highlight the …

From smoking to lung cancer: the CHRNA5/A3/B4 connection

MRD Improgo, MD Scofield, AR Tapper, PD Gardner - Oncogene, 2010 - nature.com
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key
physiological processes ranging from neurotransmission to cancer signaling. These …

Neuronal and extraneuronal nicotinic acetylcholine receptors

M Zoli, S Pucci, A Vilella, C Gotti - Current neuropharmacology, 2018 - ingentaconnect.com
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Nicotinic acetylcholine receptors and cancer

N Dang, X Meng, H Song - Biomedical reports, 2016 - spandidos-publications.com
Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer
promotion and progression through the activation of nicotinic acetylcholine receptors …

Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues

B Zhang, P Madden, J Gu, X Xing, S Sankar, J Flynn… - BMC genomics, 2017 - Springer
Background Nicotinic acetylcholine receptors (nAChRs) play an important role in cellular
physiology and human nicotine dependence, and are closely associated with many human …

Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells

DL Carlisle, X Liu, TM Hopkins, MC Swick… - Pulmonary …, 2007 - Elsevier
Nicotinic acetylcholine receptors (nAChR) are expressed on non-neuronal cell types,
including normal bronchial epithelial cells, and nicotine has been reported to cause Akt …

Nicotinic acetylcholine receptor expression in human airway correlates with lung function

DCL Lam, SY Luo, KH Fu, MMS Lui… - … of Physiology-Lung …, 2016 - journals.physiology.org
Nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nAChR s) on
bronchial epithelial cells, can regulate cellular signaling and inflammatory processes …

Expression of nicotinic acetylcholine receptor subunit genes in non–small-cell lung cancer reveals differences between smokers and nonsmokers

DC Lam, L Girard, R Ramirez, W Chau, W Suen… - Cancer research, 2007 - AACR
Nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nAChR) on
bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the …