With a rise in the need to develop anti-aging drugs, a growing number of in vivo studies
evaluating the efficacy of potential drug candidates have used doxorubicin-induced aging …

Doxorubicin-Induced Cancer Cell Senescence Shows a Time Delay Effect and Is Inhibited by
Epithelial-Mesenchymal Transition (EMT) - PMC Back to Top Skip to main content NIH NLM …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …

Somatic cells show a spontaneous decline in growth rate in continuous culture. This is not
related to elapsed time but to an increasing number of population doublings, eventually …

Senescence is a distinct cellular response induced by DNA-damaging agents and other
sublethal stressors and may provide novel benefits in cancer therapy. However, in an …

Background Cellular senescence is a specialized form of growth arrest that is generally
irreversible. Upregulated p16, p53, and p21 expression and silencing of E2F target genes …

H460 non-small cell lung, HCT116 colon and 4T1 breast tumor cell lines induced into
senescence by exposure to either etoposide or doxorubicin were able to recover …

Cellular senescence suppresses cancer by irreversibly arresting cell proliferation.
Senescent cells acquire a proinflammatory senescence-associated secretory phenotype …

Cellular senescence is defined by irreversible cell-cycle arrest and is an evolutionarily
conserved hallmark of aging. In this study, we generate senescent microglial cells via …