Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
The 4D nucleome project
Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …
structure and dynamics of the human and mouse genomes in space and time with the goal …
Challenges and guidelines toward 4D nucleome data and model standards
MA Marti-Renom, G Almouzni, WA Bickmore… - Nature …, 2018 - nature.com
Due to recent advances in experimental and theoretical approaches, the dynamic three-
dimensional organization (3D) of the nucleus has become a very active area of research in …
dimensional organization (3D) of the nucleus has become a very active area of research in …
Single‐cell imaging of genome organization and dynamics
Probing the architecture, mechanism, and dynamics of genome folding is fundamental to our
understanding of genome function in homeostasis and disease. Most chromosome …
understanding of genome function in homeostasis and disease. Most chromosome …
Coupling 1D modifications and 3D nuclear organization: data, models and function
Over the past decade, advances in molecular methods have strikingly improved the
resolution at which nuclear genome folding can be analyzed. This revealed a wealth of …
resolution at which nuclear genome folding can be analyzed. This revealed a wealth of …
Multiplexed imaging of nucleome architectures in single cells of mammalian tissue
The three-dimensional architecture of the genome affects genomic functions. Multiple
genome architectures at different length scales, including chromatin loops, domains …
genome architectures at different length scales, including chromatin loops, domains …
4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling
Recent experimental observations suggest a strong coupling between the 3D nuclear
chromosome organization and epigenomics. However, the mechanistic and functional …
chromosome organization and epigenomics. However, the mechanistic and functional …
Dynamics and interplay of nuclear architecture, genome organization, and gene expression
R Schneider, R Grosschedl - Genes & development, 2007 - genesdev.cshlp.org
The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and
dynamic. Various features of the nuclear architecture, including compartmentalization of …
dynamic. Various features of the nuclear architecture, including compartmentalization of …
Chromatin tracing and multiplexed imaging of nucleome architectures (MINA) and RNAs in single mammalian cells and tissue
The genome is hierarchically organized into several 3D architectures, including chromatin
loops, domains, compartments and regions associated with nuclear lamina and nucleoli …
loops, domains, compartments and regions associated with nuclear lamina and nucleoli …
The second decade of 3C technologies: detailed insights into nuclear organization
A Denker, W De Laat - Genes & development, 2016 - genesdev.cshlp.org
The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …
and thereby for cellular fate at large is now widely accepted. Our understanding of the …