T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …

In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell
therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in …

The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …

Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune
response to cancer. Thus, induction of their activity is the ultimate aim of all …

Simple Summary The primary issue of adoptive cell therapy is the poor in vivo persistence.
In this context, it is necessary to clarify the fundamental mechanisms of T cell dysfunction …

The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Background Current immunotherapies still have limited successful rates among cancers. It is
now recognized that T cell functional state in the tumor microenvironment (TME) is a key …

The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in
the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to …

The decline of the immune system appears to be an intractable consequence of aging,
leading to increased susceptibility to infections, reduced effectiveness of vaccination and …