Recent update on the heterogeneity of the Alzheimer's disease spectrum

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Neuropathological assessment of the Alzheimer spectrum

KA Jellinger - Journal of Neural Transmission, 2020 - Springer
Alzheimer disease (AD), the most common form of dementia globally, classically defined a
clinicopathological entity, is a heterogenous disorder with various pathobiological subtypes …

Pathobiological subtypes of Alzheimer disease

KA Jellinger - Dementia and Geriatric Cognitive Disorders, 2021 - karger.com
Alzheimer disease (AD), the most common form of dementia, is a heterogenous disorder
with various pathobiological subtypes. In addition to the 4 major subtypes based on the …

[HTML][HTML] Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

B Lam, M Masellis, M Freedman, DT Stuss… - Alzheimer's research & …, 2013 - Springer
With increasing knowledge of clinical in vivo biomarkers and the pathological intricacies of
Alzheimer's disease (AD), nosology is evolving. Harmonized consensus criteria that …

[HTML][HTML] Subtypes of Alzheimer's disease: Questions, controversy, and meaning

JW Vogel, O Hansson - Trends in Neurosciences, 2022 - cell.com
The distribution of Alzheimer's disease (AD) tau pathology varies systematically and causes
a diverse array of syndromes. This forum article provides a brief overview of key …

Biological subtypes of Alzheimer disease: a systematic review and meta-analysis

D Ferreira, A Nordberg, E Westman - Neurology, 2020 - AAN Enterprises
Objective To test the hypothesis that distinct subtypes of Alzheimer disease (AD) exist and
underlie the heterogeneity within AD, we conducted a systematic review and meta-analysis …

Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers

A Dong, JB Toledo, N Honnorat, J Doshi, E Varol… - Brain, 2017 - academic.oup.com
Abstract See Coulthard and Knight (doi: 10.1093/aww335) for a scientific commentary on
this article. Individuals with mild cognitive impairment and Alzheimer's disease clinical …

[HTML][HTML] Neuropathologic changes provide insights into key mechanisms of Alzheimer disease and related dementia

G Plascencia-Villa, G Perry - The American Journal of Pathology, 2022 - Elsevier
Alzheimer disease (AD) is a chronic disease characterized by a progressive decline in
memory and cognition. AD progression is closely correlated with neuropathologic changes …

Alzheimer disease

DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

[HTML][HTML] The neuropathological diagnosis of Alzheimer's disease—the challenges of pathological mimics and concomitant pathology

A King, I Bodi, C Troakes - Brain sciences, 2020 - mdpi.com
The definitive diagnosis of Alzheimer's disease (AD) rests with post-mortem neuropathology
despite the advent of more sensitive scanning and the search for reliable biomarkers. Even …