Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

The Precision Neurology development process implements systems theory with system
biology and neurophysiology in a parallel, bidirectional research path: a combined …

Classical biological methods involving analyses of one or several genes have been the
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …

Alzheimer's disease (AD) is a complex, multifactorial disease with a number of leading
mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to …

The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant
challenges for drug development. AD pathophysiology is progressing in a non-linear …

Recent progresses in high-throughput technologies have led to a new scenario in
investigating pathologies, named the “Omics era”, which integrate the opportunity to collect …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …

The aim of this perspective article is to stimulate radical shifts in thinking and foster further
discussion on the effective discovery, development, validation, and qualification process of …

This decade has seen the beginning of ground-breaking conceptual shifts in the research of
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …

Aetiological and clinical heterogeneity is increasingly recognized as a common
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …