The vertebrate genome is under constant threat of invasion by genetic parasites. Whether
the host can immediately recognize and respond to invading elements has been unclear …

All life forms defend their genome against DNA invasion. Eukaryotic cells recognize
incoming DNA and limit its transcription through repressive chromatin modifications. The …

Retrotransposons encompass half of the human genome and contribute to the formation of
heterochromatin, which provides nuclear structure and regulates gene expression. Here, we …

The HUSH complex recognizes and silences foreign DNA such as viruses, transposons, and
transgenes without prior exposure to its targets. Here, we show that endogenous targets of …

Abstract The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression
of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary …

The HUSH complex represses retroviruses, transposons and genes to maintain the integrity
of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but …

Transcription of integrated DNA from viruses or transposable elements is tightly regulated to
prevent pathogenesis. The Human Silencing Hub (HUSH), composed of Periphilin, TASOR …

Transposable elements (TEs) are widespread genetic parasites known to be kept under tight
transcriptional control. Here, we describe a functional connection between the mouse …

Much of what we understand about heterochromatin formation in mammals has been
extrapolated from forward genetic screens for modifiers of position‐effect variegation (PEV) …

Germ cells possess the Piwi-interacting RNA pathway to repress transposable elements and
maintain genome stability across generations. Transposable element mobilization in …