[HTML][HTML] Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study

JV Zhao, M Yao, Z Liu - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Background: COVID-19 pandemic poses a heavy burden on public health and accounts for
substantial mortality and morbidity. Proteins are building blocks of life, but specific proteins …

Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors

X Gu, S Wang, W Zhang, C Li, L Guo, Z Wang, H Li… - …, 2023 - thelancet.com
Background As a debilitating condition that can impact a whole spectrum of people and
involve multi-organ systems, long COVID has aroused the most attention than ever …

[HTML][HTML] Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer's and coronary disease pathways

L Wang, D Western, J Timsina, C Repaci, WM Song… - IScience, 2023 - cell.com
Identification of proteins dysregulated by COVID-19 infection is critically important for better
understanding of its pathophysiology, building prognostic models, and identifying new …

Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning

MA Patel, MJ Knauer, M Nicholson, M Daley… - Molecular …, 2023 - Springer
Background Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-
infection, referred to as “Long-COVID”. A lack of Long-COVID biomarkers and …

Proteomic profiling identifies novel proteins for genetic risk of severe COVID-19: the Atherosclerosis Risk in Communities Study

BT Steffen, JS Pankow, PL Lutsey… - Human molecular …, 2022 - academic.oup.com
Background Genome-wide association studies have identified six genetic variants
associated with severe COVID-19, yet the mechanisms through which they may affect …

Plasma Proteome‐Wide Mendelian Randomization Analysis Reveals Biomarkers and Therapeutic Targets for Different Stages of COVID‐19

S Krishnamoorthy, RLC Hoo… - … and Emerging Diseases, 2024 - Wiley Online Library
Background. The COVID‐19 pandemic caused by the SARS‐CoV‐2 virus has resulted in a
global health crisis with significant morbidity and mortality. While effective vaccinations have …

[HTML][HTML] Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with …

JO Bock, I Ortea - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute
respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an …

Proteomic Evolution from Acute to Post-COVID-19 Conditions

Y Mohammed, K Tran, C Carlsten… - Journal of Proteome …, 2023 - ACS Publications
Many COVID-19 survivors have post-COVID-19 conditions, and females are at a higher risk.
We sought to determine (1) how protein levels change from acute to post-COVID-19 …

Proteomics approaches to long COVID: status and outlooks

X Liang, Y Wang, T Guo - Life Medicine, 2023 - academic.oup.com
While we are facing continuous threat from SARS-CoV-2, which causes the global COVID-
19 pandemic, the post-acute sequelae of SARS-CoV-2 infection (PASC) emerge as new …

Circulating proteins to predict COVID-19 severity

CY Su, S Zhou, E Gonzalez-Kozlova… - Scientific Reports, 2023 - nature.com
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully
understood. To approach this problem, we measured 4701 circulating human protein …