As a hallmark of immunological aging, low-grade, chronic inflammation with accumulation of
effector memory T cells contributes to increased susceptibility to many aging-related …

Summary Regulatory T‐cell (Treg, CD 4+ CD 25+) dysfunction is suspected to play a key
role in immune senescence and contributes to increased susceptibility to diseases with age …

Objective An upward trend in life expectancy has been observed in a majority of developed
countries and leading to increasing in aging-related diseases. Aging is a risk factor for the …

The immune system is a tightly regulated network which allows the development of defense
mechanisms against foreign antigens and tolerance toward self-antigens. Regulatory T cells …

The aging process causes profound restructuring of the host immune system, typically
associated with declining host protection against cancer and infection. In the case of T cells …

A hallmark of aging is the progressive deterioration of immune function. Age-related immune
suppression increases susceptibility to infectious diseases and cancer, significant causes of …

Constant exposure to new and persisting antigens and the need to replace cellular attrition
with newly built cells lead to profound remodeling of the immune system after the age of 50 …

Age-related deviations of the immune system contribute to a higher likelihood of infections,
cancer, and autoimmunity in the elderly. Senescence of T-lymphocytes is characterized by …

In the last century, we have seen a dramatic rise in the number of older persons globally, a
trend known as the grey (or silver) tsunami. People live markedly longer than their …

Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …