Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate
and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which …

Background Cisplatin is widely used for chemotherapy of head and neck squamous cell
carcinoma. However, details of the molecular mechanism responsible for cisplatin …

Resistance to cisplatin is a major obstacle to successful treatment of head and neck
squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this …

Chemotherapy resistance is a huge barrier for head and neck cancer (HNC) patients and
therefore requires close attention to understand its underlay mechanisms for effective …

Oral cancer is an aggressive disease with the propensity for local recurrence and distal
metastasis in the head and neck region. Currently, cisplatin-based chemotherapy or …

Oxaliplatin was the first platinum drug with proven activity against colorectal tumors,
becoming a standard in the management of this malignancy. It is also considered for the …

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various
types of cancer for decades, drug resistance has been a major clinical impediment. In …

Purpose: Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum (II),
CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN) …

Cisplatin (CDDP) is widely used for chemotherapy of many malignancies, especially of oral
squamous cell carcinoma (SCC). However, because the mechanism of resistance to CDDP …

Cisplatin-based chemotherapy has been used for more than four decades as a standard
therapeutic option in several tumor entities. However, being a multifaceted and …