Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Over the last 50 years, major improvements have been made in our understanding of the
driving forces, both parallel and opposing, that lead to aging and cancer. Many theories on …

Cellular senescence is a complex stress response that permanently arrests the proliferation
of cells at risk for oncogenic transformation. However, senescent cells can also drive …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Cancer is an age‐related disease in organisms with renewable tissues. A malignant tumor
arises in part from genomic damage, which can also drive age‐related degeneration …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

Cancer is largely a disease of older people. With the relatively recent expansive growth
within the geriatric population, a number of pressing biological and clinical questions that …

The ageing of populations worldwide is leading to an unprecedented increase in cancer
cases and fatalities. Understanding the links between cancer and ageing is therefore more …