JR Aunan, WC Cho, K Søreide - Aging and disease, 2017 - ncbi.nlm.nih.gov
Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control …
C Falandry, M Bonnefoy, G Freyer… - Journal of Clinical …, 2014 - ascopubs.org
Over the last 50 years, major improvements have been made in our understanding of the driving forces, both parallel and opposing, that lead to aging and cancer. Many theories on …
CD Wiley, J Campisi - Cell metabolism, 2016 - cell.com
Cellular senescence is a complex stress response that permanently arrests the proliferation of cells at risk for oncogenic transformation. However, senescent cells can also drive …
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for …
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Cancer is an age‐related disease in organisms with renewable tissues. A malignant tumor arises in part from genomic damage, which can also drive age‐related degeneration …
Cancer is largely a disease of older people. With the relatively recent expansive growth within the geriatric population, a number of pressing biological and clinical questions that …
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more …