Isolation and biological activity of natural chalcones based on antibacterial mechanism classification

S Wang, C Li, L Zhang, B Sun, Y Cui, F Sang - Bioorganic & Medicinal …, 2023 - Elsevier
Bacterial infection, which is still one of the leading causes of death in humans, poses an
enormous threat to the worldwide public health system. Antibiotics are the primary …

Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

W Dan, J Dai - European journal of medicinal chemistry, 2020 - Elsevier
Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

Pharmacotherapeutics applications and chemistry of chalcone derivatives

JS Dhaliwal, S Moshawih, KW Goh, MJ Loy… - Molecules, 2022 - mdpi.com
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …

[PDF][PDF] Recent advances in chalcones as antiinfective agents

D Gupta, D Jain, P Trivedi - Int. J. Chem. Sci, 2010 - hakon-art.com
Chalcones are important precursors of flavonoids and isoflavonoids. Naturally occuring and
synthetic chalcones show various biological effects, eg anti-inflammatory, antitumour …

Biological role of chalcones in medicinal chemistry

S Tekale, S Mashele, O Pooe, S Thore… - … in epidemiology and …, 2020 - books.google.com
Chalcones are promising synthons and bioactive scaffolds of great medicinal interest due to
their numerous pharmacological and biological activities. They are well recognized to …

Recent advances on the synthesis of chalcones with antimicrobial activities: A brief review

M Ritter, R Mastelari Martins, D Dias… - Letters in Organic …, 2014 - ingentaconnect.com
The increasing resistance of bacteria and fungi to antimicrobial drugs has been a matter of
concern in public health in the last decades. The continuing need for novel therapeutic …

Chalcone derivatives and their antibacterial activities: Current development

M Xu, P Wu, F Shen, J Ji, KP Rakesh - Bioorganic Chemistry, 2019 - Elsevier
The increase in antibiotic resistance due to various factors has encouraged the look for
novel compounds which are active against multidrug-resistant pathogens. In this framework …

Synthesis of chalcones and their antimicrobial and drug potentiating activities

ATL Dos Santos, JB de Araújo-Neto, MMC da Silva… - Microbial …, 2023 - Elsevier
The increased resistance of microorganisms to antimicrobial drugs makes it necessary to
search for new active compounds, such as chalcones. Their simple chemical structure …

Structure–activity relationship of antibacterial chalcones

HP Ávila, EFA Smânia, F Delle Monache… - Bioorganic & medicinal …, 2008 - Elsevier
The antibacterial activity of 31 chalcones was tested against bacterial strains, Bacillus
cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC …

Chalcone: a promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …