[HTML][HTML] Host and environmental factors influencing individual human cytokine responses
R Ter Horst, M Jaeger, SP Smeekens, M Oosting… - Cell, 2016 - cell.com
Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …
immune responses. In three studies within the Human Functional Genomics Project, we …
Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
The immune response to pathogens varies substantially among people. Whereas both
genetic and nongenetic factors contribute to interperson variation, their relative contributions …
genetic and nongenetic factors contribute to interperson variation, their relative contributions …
[HTML][HTML] Linking the human gut microbiome to inflammatory cytokine production capacity
Gut microbial dysbioses are linked to aberrant immune responses, which are often
accompanied by abnormal production of inflammatory cytokines. As part of the Human …
accompanied by abnormal production of inflammatory cytokines. As part of the Human …
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
Little is known about the inter-individual variation of cytokine responses to different
pathogens in healthy individuals. To systematically describe cytokine responses elicited by …
pathogens in healthy individuals. To systematically describe cytokine responses elicited by …
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
B Piasecka, D Duffy, A Urrutia… - Proceedings of the …, 2018 - National Acad Sciences
The contribution of host genetic and nongenetic factors to immunological differences in
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …
[HTML][HTML] Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Background Humoral immune responses to infectious agents or vaccination vary
substantially among individuals, and many of the factors responsible for this variability …
substantially among individuals, and many of the factors responsible for this variability …
[HTML][HTML] Complex host genetics influence the microbiome in inflammatory bowel disease
Background Human genetics and host-associated microbial communities have been
associated independently with a wide range of chronic diseases. One of the strongest …
associated independently with a wide range of chronic diseases. One of the strongest …
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
The quantification and characterization of circulating immune cells provide key indicators of
human health and disease. To identify the relative effects of environmental and genetic …
human health and disease. To identify the relative effects of environmental and genetic …
Cytokine genes and disease susceptibility
WER Ollier - Cytokine, 2004 - Elsevier
Complex networks of cytokines interact in a dynamic way to homeostatically regulate
immune responses and other biological pathways. It is, therefore, not surprising that …
immune responses and other biological pathways. It is, therefore, not surprising that …
Human genetic variation and the gut microbiome in disease
AB Hall, AC Tolonen, RJ Xavier - Nature Reviews Genetics, 2017 - nature.com
Taxonomic and functional changes to the composition of the gut microbiome have been
implicated in multiple human diseases. Recent microbiome genome-wide association …
implicated in multiple human diseases. Recent microbiome genome-wide association …