It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …

Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …

Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …

Background We previously investigated the association between 5 “first-generation”
measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study …

Lung cancer is considered an age-associated disease, whose progression is in part due to
accumulation of genomic instability as well as age-related decline in system integrity and …

Background DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …