Several studies have shown a reduced efficacy of influenza vaccines in the elderly
compared to young adults. In this study, we evaluated the immunogenicity and protective …

Aging is associated with diminished immune system function, which renders old people
vulnerable to influenza infection and also less responsive to influenza vaccination. This …

Inactivated influenza vaccines are known to be less immunogenic in human elderly in
regards to serologic antibody response induced by vaccination. Accumulating evidence …

Influenza vaccines are less effective in older people than younger people. This impaired
ability to protect older people from influenza viral lung infection has important implications as …

Influenza virus-like particles (VLPs) were produced in Sf9 insect cells by co-expressing the
matrix protein M1 and the surface glycoproteins hemagglutinin (HA) and neuraminidase …

Influenza infections may cause serious morbidity, as well as mortality in the elderly. In the
present study we vaccinated old and young mice of two strains with three synthetic …

While influenza immunization significantly reduces the risk of pneumonia and associated
deaths, vaccination of elderly only affords 30–50% protection against influenza disease. The …

Aging is associated with a decline in immune function and the elderly are therefore more
susceptible to infectious disease and less responsive to vaccination. Influenza antigens …

Influenza is a leading cause of morbidity and mortality in older persons. The current
influenza vaccine is only modestly successful, in part because of an age-related decline in …

Background Influenza virus infection causes significant morbidity and mortality worldwide.
Humans fail to make a universally protective memory response to influenza A because of …