Phenolic compounds that cross the blood–brain barrier exert positive health effects as central nervous system antioxidants

D Velásquez-Jiménez, DA Corella-Salazar… - Food & Function, 2021 - pubs.rsc.org
The blood–brain barrier (BBB) is a physical structure whose main function is to strictly
regulate access to circulating compounds into the central nervous system (CNS). Vegetable …

Polyphenols journey through blood-brain barrier towards neuronal protection

I Figueira, G Garcia, RC Pimpão, AP Terrasso… - Scientific reports, 2017 - nature.com
Age-related complications such as neurodegenerative disorders are increasing and remain
cureless. The possibility of altering the progression or the development of these …

Low molecular weight (poly) phenol metabolites across the blood-brain barrier: the underexplored journey

R Carecho, D Carregosa, CN Dos Santos - Brain Plasticity, 2020 - content.iospress.com
The world of (poly) phenols arising from dietary sources has been significantly amplified with
the discovery of low molecular weight (LMW)(poly) phenol metabolites resulting from phase I …

Flavonoid transport across RBE4 cells: A blood-brain barrier model

A Faria, D Pestana, D Teixeira, J Azevedo… - Cellular and Molecular …, 2010 - degruyter.com
There is a growing interest in dietary therapeutic strategies to combat oxidative stress-
induced damage to the Central Nervous System (CNS), which is associated with a number …

Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

I Figueira, L Tavares, C Jardim, I Costa… - European journal of …, 2019 - Springer
Purpose Epidemiological and intervention studies have attempted to link the health effects of
a diet rich in fruits and vegetables with the consumption of polyphenols and their impact in …

Identification and quantification of (poly) phenol and methylxanthine metabolites in human cerebrospinal fluid: Evidence of their ability to cross the BBB

M Le Sayec, D Carregosa, K Khalifa, C de Lucia… - Food & Function, 2023 - pubs.rsc.org
Increasing evidence suggests that dietary (poly) phenols and methylxanthines have
neuroprotective effects; however, little is known about whether they can cross the blood …

Flavonoid transport across blood-brain barrier: Implication for their direct neuroprotective actions

A Faria, N Mateus, C Calhau - Nutrition and Aging, 2012 - content.iospress.com
Epidemiological and dietary intervention studies in humans and animals indicate that
flavonoid consumption may be capable of promoting brain health. However, the knowledge …

Polyphenols and their impact on the prevention of neurodegenerative diseases and development

I Grabska-Kobyłecka, P Szpakowski, A Król… - Nutrients, 2023 - mdpi.com
It is well known that neurodegenerative diseases' development and progression are
accelerated due to oxidative stress and inflammation, which result in impairment of …

Insights into the putative catechin and epicatechin transport across blood-brain barrier

A Faria, D Pestana, D Teixeira, PO Couraud… - Food & function, 2011 - pubs.rsc.org
The identification of mechanisms associated with phenolic neuroprotection is delayed due to
a lack of information regarding the ability of phenolic compounds to enter the central …

Plant phenolics: Bioavailability as a key determinant of their potential health-promoting applications

P Cosme, AB Rodríguez, J Espino, M Garrido - Antioxidants, 2020 - mdpi.com
Phenolic compounds are secondary metabolites widely spread throughout the plant
kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic …