Vaccination-induced protection against influenza is greatly diminished and increasingly
heterogeneous with age. We investigated longitudinally (up to five timepoints) a cohort of …

Seasonal influenza outbreaks, especially in high-risk groups such as the elderly, represent
an important public health problem. Prevailing inadequate efficacy of seasonal vaccines is a …

Age-related declines in immune response pose a challenge in combating diseases later in
life. Influenza (flu) infection remains a significant burden on older populations and often …

Age‐associated immune changes and pre‐existing influenza immunity are hypothesized to
reduce influenza vaccine effectiveness in older adults, although the contribution of each …

Influenza infections are responsible for significant morbidity and mortality each year, with the
highest infection rates found in the elderly population. The main strategy to reduce the …

Clinical data showed sex variability in the immune response to influenza vaccination, this
study aimed to investigate differentially expressed genes (DEGs) that contribute to sex-bias …

Effective vaccine‐induced immune responses are particularly essential in older adults who
face an increased risk of immunosenescence. However, the complexity and variability of the …

Page 2 of 3 Leng and Shaw Immunity & Ageing (2023) 20: 69 and prior season post-
vaccination HAI antibody titers had significant and independent impact on pre-existing …

Background With increasing age, overall health declines while systemic levels of
inflammatory mediators tend to increase. Although the underlying mechanisms are poorly …

Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to
suboptimal immune responses in older adults to standard-dose influenza vaccines, which …