[HTML][HTML] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium

F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong… - Cell stem cell, 2020 - cell.com
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …

[HTML][HTML] SARS-CoV-2 targets glial cells in human cortical organoids

CL McMahon, H Staples, M Gazi, R Carrion, J Hsieh - Stem Cell Reports, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) patients have manifested a variety of
neurological complications, and there is still much to reveal regarding the neurotropism of …

[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids

L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul… - Cell stem cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

P Mesci, JS de Souza, L Martin-Sancho, A Macia… - PLoS …, 2022 - journals.plos.org
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative
agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by …

In SARS-CoV-2, astrocytes are in it for the long haul

S Huang, G Fishell - … of the National Academy of Sciences, 2022 - National Acad Sciences
The most dire consequences of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection may not manifest during the initial infection but appear later and are …

Tropism of SARS-CoV-2 for human cortical astrocytes

MG Andrews, T Mukhtar, UC Eze… - Proceedings of the …, 2022 - National Acad Sciences
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety
of cell types impacting the function of vital organ systems, with particularly severe impact on …

Neuropilin-1 mediates SARS-CoV-2 infection of astrocytes in brain organoids, inducing inflammation leading to dysfunction and death of neurons

W Kong, M Montano, MJ Corley, E Helmy, H Kobayashi… - MBio, 2022 - Am Soc Microbiol
ABSTRACT Coronavirus disease 2019 (COVID-19) is frequently associated with
neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

SARS-CoV-2 infects human neural progenitor cells and brain organoids

BZ Zhang, H Chu, S Han, H Shuai, J Deng, Y Hu… - Cell research, 2020 - nature.com
Dear Editor, Coronavirus disease 2019 (COVID-19) caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 has resulted in over 13 million …

Infection of brain organoids and 2D cortical neurons with SARS-CoV-2 pseudovirus

SA Yi, KH Nam, J Yun, D Gim, D Joe, YH Kim, HJ Kim… - Viruses, 2020 - mdpi.com
Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs
along with multiple symptoms continue to be reported. However, the susceptibility of the …

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …