[HTML][HTML] DNA methylation predicts age and provides insight into exceptional longevity of bats

GS Wilkinson, DM Adams, A Haghani, AT Lu… - Nature …, 2021 - nature.com
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …

[HTML][HTML] Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats

Z Huang, CV Whelan, NM Foley, D Jebb… - Nature ecology & …, 2019 - nature.com
Bats are the longest-lived mammals, given their body size. However, the underlying
molecular mechanisms of their extended healthspans are poorly understood. To address …

Application of a novel molecular method to age free‐living wild Bechstein's bats

PGR Wright, F Mathews, H Schofield… - Molecular ecology …, 2018 - Wiley Online Library
The age profile of populations fundamentally affects their conservation status. Yet, age is
frequently difficult to assess in wild animals. Here, we assessed the use of DNA methylation …

Growing old, yet staying young: the role of telomeres in bats' exceptional longevity

NM Foley, GM Hughes, Z Huang, M Clarke, D Jebb… - Science …, 2018 - science.org
Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …

Bats and birds: exceptional longevity despite high metabolic rates

J Munshi-South, GS Wilkinson - Ageing research reviews, 2010 - Elsevier
Bats and birds live substantially longer on average than non-flying mammals of similar body
size. The combination of small body size, high metabolic rates, and long lifespan in bats and …

DNA methylation clocks for dogs and humans

S Horvath, AT Lu, A Haghani… - Proceedings of the …, 2022 - National Acad Sciences
DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …

[HTML][HTML] Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii

I Seim, X Fang, Z Xiong, AV Lobanov, Z Huang… - Nature …, 2013 - nature.com
Bats account for one-fifth of mammalian species, are the only mammals with powered flight,
and are among the few animals that echolocate. The insect-eating Brandt's bat (Myotis …

[HTML][HTML] Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome

T Wang, J Ma, AN Hogan, S Fong, K Licon, B Tsui… - Cell systems, 2020 - cell.com
All mammals progress through similar physiological stages throughout life, from early
development to puberty, aging, and death. Yet, the extent to which this conserved …

Age estimation in a long‐lived seabird (Ardenna tenuirostris) using DNA methylation‐based biomarkers

R De Paoli‐Iseppi, BE Deagle… - Molecular ecology …, 2019 - Wiley Online Library
Age structure is a fundamental aspect of animal population biology. Age is strongly related
to individual physiological condition, reproductive potential and mortality rate. Currently …

Drivers of longitudinal telomere dynamics in a long‐lived bat species, Myotis myotis

NM Foley, EJ Petit, T Brazier, JA Finarelli… - Molecular …, 2020 - Wiley Online Library
Age‐related telomere shortening is considered a hallmark of the ageing process. However,
a recent cross‐sectional ageing study of relative telomere length (rTL) in bats failed to detect …