SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied
by chronic neurological sequelae such as cognitive decline and mood disorder, but the …

SARS-CoV-2 spike protein accumulation in the skull-meninges-brain axis: potential implications for long-term neurological complications in post-COVID-19

Z Rong, H Mai, S Kapoor, VG Puelles, J Czogalla… - BioRxiv, 2023 - biorxiv.org
ABSTRACT Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of …

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

MG Frank, KH Nguyen, JB Ball, S Hopkins… - Brain, behavior, and …, 2022 - Elsevier
SARS-CoV-2 infection produces neuroinflammation as well as neurological, cognitive (ie,
brain fog), and neuropsychiatric symptoms (eg, depression, anxiety), which can persist for …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

A Fernández-Castañeda, P Lu, AC Geraghty, E Song… - BioRxiv, 2022 - ncbi.nlm.nih.gov
Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
infection frequently experience lingering neurological symptoms, including impairment in …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis

AL Soung, A Vanderheiden, AS Nordvig, CA Sissoko… - Brain, 2022 - academic.oup.com
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
associated with acute and postacute cognitive and neuropsychiatric symptoms including …

[HTML][HTML] SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

F Crunfli, VC Carregari, FP Veras, PH Vendramini… - MedRxiv, 2021 - medrxiv.org
One increasingly documented tendency of COVID-19 patients is to exhibit neuropsychiatric
and neurological symptoms. Here we found that anxiety and cognitive impairment are …

[HTML][HTML] Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

A Fernández-Castañeda, P Lu, AC Geraghty, E Song… - Cell, 2022 - cell.com
COVID survivors frequently experience lingering neurological symptoms that resemble
cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial …