Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and
silencing,,. However, we recently discovered the presence of cytoplasmic chromatin …

Cellular senescence is triggered by various distinct stresses and characterized by a
permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors …

Replicative crisis is a senescence-independent process that acts as a final barrier against
oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle …

Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is
essential for cellular senescence. cGAS promotes inflammatory senescence-associated …

Two major mechanisms have been causally implicated in the establishment of cellular
senescence: the activation of the DNA damage response (DDR) pathway and the formation …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this,
cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated …

INTRODUCTION Cyclic guanosine monophosphate (GMP)–adenosine monophosphate
(AMP) synthase (cGAS) detects microbial DNA in the cytosol to trigger innate immune …

Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor
effects of several therapies, including radiation and chemotherapeutic drugs. Senescence …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …