The house mouse (Mus musculus) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …
Mammalian embryogenesis is characterized by rapid cellular proliferation and diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …
Cellular responses to stimuli are rapid and continuous and yet the vast majority of investigations of transcriptional responses during developmental transitions typically use …
INTRODUCTION Metazoan development represents a big jump in complexity compared with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …
M Werber, L Wittler, B Timmermann, P Grote… - …, 2014 - journals.biologists.com
Differential gene expression is a prerequisite for the formation of multiple cell types from the fertilized egg during embryogenesis. Understanding the gene regulatory networks …
Mouse embryonic development is a canonical model system for studying mammalian cell fate acquisition. Recently, single-cell atlases comprehensively charted embryonic …
Y Xu, T Zhang, Q Zhou, M Hu, Y Qi, Y Xue, L Wang… - BioRxiv, 2021 - biorxiv.org
The early window of human embryogenesis is largely a black box for developmental biologists. Here we probed the cellular diversity of 4-to 6-week human embryos when …
PJ Rugg-Gunn, N Moris, PPL Tam - Development, 2023 - journals.biologists.com
Recent years have seen exciting progress across human embryo research, including new methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …
Our understanding of human pre-implantation development is limited by the availability of human embryos and cannot completely rely on mouse studies. Petropoulos et al. now …