Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination

ET Stone, M Hassert, E Geerling, C Wagner, JD Brien… - Cell reports, 2022 - cell.com
Powassan virus (POWV) is a tick-borne pathogen for which humans are an incidental host.
POWV infection can be fatal or result in long-term neurological sequelae; however, there are …

A virus-like particle-based vaccine candidate against the tick-borne powassan virus induces neutralizing antibodies in a mouse model

V Cimica, S Saleem, E Matuczinski, D Adams-Fish… - Pathogens, 2021 - mdpi.com
Powassan virus (POWV) is a tick-borne flavivirus circulating in North America and the
Russian Far East that can cause severe neuroinvasive diseases, including encephalitis …

Characterization of live-attenuated Powassan virus vaccine candidates identifies an efficacious prime-boost strategy for mitigating Powassan virus disease in a murine …

AM Cheung, EZ Yip, AW Ashbrook, N Goonawardane… - Vaccines, 2023 - mdpi.com
Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in
humans. The lack of treatment or prevention strategies for POWV disease underscores the …

A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus

H Choi, SB Kudchodkar, M Ho… - PLOS Neglected …, 2020 - journals.plos.org
Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United
States and North America. Like Zika virus, POWV is a member of the family Flaviviridae …

Recapitulation of the Powassan virus life cycle in cell culture

J Song, J Hong, C Yang, Y Zhang, Z Li, P He, Q Ding - Mbio, 2024 - Am Soc Microbiol
Powassan virus (POWV) is a tick-borne flavivirus known for causing fatal neuroinvasive
diseases in humans. Recently, there has been a noticeable increase in POWV infections …

Immune cell targets of infection at the tick-skin interface during Powassan virus transmission

ME Hermance, RI Santos, BC Kelly, G Valbuena… - PLoS …, 2016 - journals.plos.org
Powassan virus (POWV) is a tick-borne flavivirus that can result in a severe neuroinvasive
disease with 50% of survivors displaying long-term neurological sequelae. Human POWV …

Immunoinformatics and computational approaches driven designing a novel vaccine candidate against Powassan virus

TL Nguyen, H Kim - Scientific Reports, 2024 - nature.com
Powassan virus (POWV) is an arthropod-borne virus (arbovirus) capable of causing severe
illness in humans for severe neurological complications, and its incidence has been on the …

A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice

RJ Malonis, GI Georgiev, D Haslwanter… - PLoS …, 2022 - journals.plos.org
Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe
neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat …

Tick saliva enhances Powassan virus transmission to the host, influencing its dissemination and the course of disease

ME Hermance, S Thangamani - Journal of Virology, 2015 - Am Soc Microbiol
Powassan virus (POWV) is an encephalitic tick-borne flavivirus which can result in serious
neuroinvasive disease with up to a 10% case fatality rate. The study objective was to …

Vector competence of human-biting ticks Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis for Powassan virus

R Sharma, DW Cozens, PM Armstrong, DE Brackney - Parasites & Vectors, 2021 - Springer
Background Powassan virus (POWV; genus Flavivirus) is the sole North American member
of the tick-borne encephalitis sero-complex and an increasing public health threat in the …