Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro
Although epithelial-mesenchymal transition (EMT) is a common feature of fibrotic lung
disease, its role in fibrogenesis is controversial. Recently, aberrant basaloid cells were …
disease, its role in fibrogenesis is controversial. Recently, aberrant basaloid cells were …
Alveolar basal cells differentiate towards secretory epithelial-and aberrant basaloid-like cells in vitro
In idiopathic pulmonary fibrosis (IPF), keratin (KRT) 17+/KRT5+ basal and KRT17+/KRT5−
aberrant basaloid cells are atypically present within the alveolar space. We previously …
aberrant basaloid cells are atypically present within the alveolar space. We previously …
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
JJ Kathiriya, C Wang, M Zhou, A Brumwell… - Nature cell …, 2022 - nature.com
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
[HTML][HTML] Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high
morbidity and mortality. The cellular source of the fibrotic process is currently under debate …
morbidity and mortality. The cellular source of the fibrotic process is currently under debate …
[HTML][HTML] Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung
disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to …
disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to …
Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair
JJ Kathiriya, C Wang, A Brumwell, M Cassandras… - BioRxiv, 2020 - biorxiv.org
Understanding differential lineage potential of orthologous stem cells across species can
shed light on human disease. Here, utilizing 3D organoids, single cell RNAseq, and …
shed light on human disease. Here, utilizing 3D organoids, single cell RNAseq, and …
Single-cell reconstruction of human basal cell diversity in normal and idiopathic pulmonary fibrosis lungs
Rationale: Declining lung function in patients with interstitial lung disease is accompanied
by epithelial remodeling and progressive scarring of the gas-exchange region. There is a …
by epithelial remodeling and progressive scarring of the gas-exchange region. There is a …
Understanding alveolarization to induce lung regeneration
JA Rodríguez-Castillo, DB Pérez, A Ntokou… - Respiratory …, 2018 - Springer
Background Gas exchange represents the key physiological function of the lung, and is
dependent upon proper formation of the delicate alveolar structure. Malformation or …
dependent upon proper formation of the delicate alveolar structure. Malformation or …
Platform effects on regeneration by pulmonary basal cells as evaluated by single-cell RNA sequencing
Cell-based therapies have shown promise for treating myriad chronic pulmonary diseases
through direct application of epithelial progenitors or by way of engineered tissue grafts or …
through direct application of epithelial progenitors or by way of engineered tissue grafts or …
[HTML][HTML] Single-cell RNA sequencing identifies TGF-β as a key regenerative cue following LPS-induced lung injury
KA Riemondy, NL Jansing, P Jiang, EF Redente… - JCI insight, 2019 - ncbi.nlm.nih.gov
Many lung diseases result from a failure of efficient regeneration of damaged alveolar
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace …
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace …