Ergothioneine (EGT) is a bioactive compound derived from certain edible mushrooms. The
activation of hepatic stellate cells (HSCs) is critically involved in the etiology of liver fibrosis …

Our study aimed to explore effects of a characterized ethanol extract of Rosa rugosa (ERS)
on hepatic stellate cells (HSCs) activation and mouse liver fibrosis and their molecular …

The liver-enriched transcription factor Forkhead Box A2 (FOXA2) has been reported to be
involved in bile acid homeostasis and bile duct development. However, the role of FOXA2 in …

Despite great progress in understanding the activation of hepatic stellate cells (HSCs)
during liver fibrosis, therapeutic approaches to inhibit HSC activation remain very limited …

Background & aims Liver fibrosis characterizes advanced chronic liver disease, and
persistent activation of hepatic stellate cells (HSCs) is the primary cause of excessive …

Liver fibrosis is a pathological process as a result of intrahepatic deposition of excessive
ECM. EMT of hepatocytes and activation of HSCs both play important roles in the etiology of …

This study aimed to investigate the beneficial effects of myricetin in a diet-induced
nonalcoholic steatohepatitis (NASH) model and the underlying mechanism. C57BL/6J mice …

The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a
characteristic response to acute or chronic liver injury. Mice were randomized to bile duct …

Hepatic stellate cells (HSCs) are a major source of fibrogenic cells and play a central role in
liver fibrogenesis. HSC activation depends on metabolic activation, for which it is well …

The mechanisms of hepatic stellate cell (HSC) activation and the development of liver
fibrosis are not fully understood. Here, we show that deletion of a nuclear seven …