Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …

Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly,
and causes death due to dementia. The main pathogenic feature connected with the …

Exploring small-molecule acetylcholinesterase (AChE) inhibitors to slow the breakdown of
acetylcholine (Ach) represents the mainstream direction for Alzheimer's disease (AD) …

The cholinergic hypothesis has long been a “polar star” in drug discovery for Alzheimer's
disease (AD), resulting in many small molecules and biological drug candidates. Most of the …

N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …

In the brain, acetylcholine (ACh) is regarded as one of the major neurotransmitters. During
the advancement of Alzheimer's disease (AD) cholinergic deficits occur and this can lead to …

Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Alzheimer's disease (AD) is a severe neurodegenerative disorder of different brain regions
accompanied by distresses and affecting more than 25 million people in the world. This …

Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …