Abstract Purpose of Review Runt-related transcription factors (RUNX) play critical roles in
skeletal development, metabolism, and diseases. In mammals, three RUNX members …

Despite years of research investigating osteoblast differentiation, the mechanisms by which
transcription factors regulate osteoblast maturation, bone formation, and bone homeostasis …

Skeletal development is tightly coordinated by chondrocytes and osteoblasts, which are
derived from skeletal progenitors, and distinct cell-type gene regulatory programs underlie …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Runx2/Cbfa/AML3 is a member of the runt homology domain family of transcription factors,
essential for osteoblast differentiation and bone formation. Defining the molecular …

Runt-related transcription factor 2 (RUNX2) is a key transcription factor for bone formation
and osteoblast differentiation. Various signaling pathways and mechanisms that regulate the …

Global gene deletion studies in mice and humans have established the pivotal role of runt
related transcription factor‐2 (Runx2) in both intramembranous and endochondral …

Runt‐related transcription factor 2 (Runx2) has been shown to regulate osteoblast
differentiation by directly or indirectly regulating numerous osteoblast‐related genes …

Osteogenesis is the process of new bone formation where transcription factors play an
important role in controlling cell proliferation and differentiation. Runt-related transcription …

Objective Runt-related transcription factor 2 (Runx2) and Osterix (Osx) are the master
transcription factors in bone formation. Nonetheless, genes acting downstream of both …