The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

With a falling birth rate and increasing life expectancy we are experiencing dramatic
demographic changes that result in an ever ageing population. Aging is accompanied by …

Average life expectancy is continuously rising in all developed countries, leading to an ever-
increasing elderly population. Of the many functions of the body affected by the complex …

Successful vaccination of the elderly against important infectious pathogens that cause high
morbidity and mortality represents a growing public health priority. Building on the theme of …

Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

Highlights•Immunosenescence leads to increased susceptibility to infection and decreased
vaccine response.•Heme-oxygenase gene expression may be an important element in age …

Prolonged life expectancy in the 20th century has been one of humankind's greatest
triumphs. However, the substantial increase in the human life span has ushered in a new …

The immune system of the elderly is particularly susceptible to infectious diseases and
displays reduced response to vaccination. The current vaccines, designed for young and …