Roles of transposable elements in the regulation of mammalian transcription

R Fueyo, J Judd, C Feschotte, J Wysocka - Nature reviews Molecular …, 2022 - nature.com
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes

V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …

Transposable elements as genetic regulatory substrates in early development

WD Gifford, SL Pfaff, TS Macfarlan - Trends in cell biology, 2013 - cell.com
The abundance and ancient origins of transposable elements (TEs) in eukaryotic genomes
has spawned research into the potential symbiotic relationship between these elements and …

TFs for TEs: the transcription factor repertoire of mammalian transposable elements

C Hermant, ME Torres-Padilla - Genes & development, 2021 - genesdev.cshlp.org
Transposable elements (TEs) are genetic elements capable of changing position within the
genome. Although their mobilization can constitute a threat to genome integrity, nearly half …

[HTML][HTML] Tissue-specific usage of transposable element-derived promoters in mouse development

B Miao, S Fu, C Lyu, P Gontarz, T Wang, B Zhang - Genome biology, 2020 - Springer
Abstract Background Transposable elements (TEs) are a significant component of
eukaryotic genomes and play essential roles in genome evolution. Mounting evidence …

[HTML][HTML] Transposable elements in the mammalian embryo: pioneers surviving through stealth and service

P Gerdes, SR Richardson, DL Mager, GJ Faulkner - Genome biology, 2016 - Springer
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary
time, TE insertions can supply new promoter, enhancer, and insulator elements to protein …

[HTML][HTML] Transposable elements generate regulatory novelty in a tissue-specific fashion

M Trizzino, A Kapusta, CD Brown - BMC genomics, 2018 - Springer
Background Transposable elements (TE) are an important source of evolutionary novelty in
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …

The impact of transposable elements on mammalian development

JL Garcia-Perez, TJ Widmann, IR Adams - Development, 2016 - journals.biologists.com
Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …

[HTML][HTML] Role of transposable elements in gene regulation in the human genome

A Ali, K Han, P Liang - Life, 2021 - mdpi.com
Transposable elements (TEs), also known as mobile elements (MEs), are interspersed
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …

Widespread contribution of transposable elements to the innovation of gene regulatory networks

V Sundaram, Y Cheng, Z Ma, D Li, X Xing… - Genome …, 2014 - genome.cshlp.org
Transposable elements (TEs) have been shown to contain functional binding sites for
certain transcription factors (TFs). However, the extent to which TEs contribute to the …