Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a
consequence display a radically altered phenotype that is thought to impair tissue function …

Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead.
They noted sustained cell-cycle arrest after repeated subculturing of human primary cells …

The study of cellular senescence and proliferative lifespan is becoming increasingly
important because of the promises of autologous cell therapy, the need for model systems …

Cell Senescence in Human Aging: Page 1 In Vivo 14:29-34 Fossel 1 Cell Senescence in
Human Aging: A Review of the Theory In Vivo 14:29-34, 2000 Michael Fossel, MD, PhD …

The contribution of cellular senescence to a diverse range of biological processes, including
normal physiology, ageing, and pathology were long overlooked but have now taken centre …

Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells
remain metabolically active and often acquire a distinctive bioactive secretory phenotype …

Half a century is fast approaching since Hayflick and colleagues formally described the
limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961) …