Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …

A novel cell‐free DNA methylation‐based model improves the early detection of colorectal cancer

X Wu, Y Zhang, T Hu, X He, Y Zou, Q Deng… - Molecular …, 2021 - Wiley Online Library
Screening for early‐stage disease is vital for reducing colorectal cancer (CRC)‐related
mortality. Methylation of circulating tumor DNA has been previously used for various types of …

A study of hypermethylated circulating tumor DNA as a universal colorectal cancer biomarker

S Garrigou, G Perkins, F Garlan, C Normand… - Clinical …, 2016 - academic.oup.com
Abstract BACKGROUND Circulating tumor DNA (ctDNA) has emerged as a good candidate
for tracking tumor dynamics in different cancer types, potentially avoiding repeated tumor …

Early detection of molecular residual disease and risk stratification for stage I to III colorectal cancer via circulating tumor DNA methylation

S Mo, L Ye, D Wang, L Han, S Zhou, H Wang… - JAMA …, 2023 - jamanetwork.com
Importance Detection of molecular residual disease and risk stratification as early as
possible may improve the treatment of patients with cancer. Efficient pragmatic tests are …

[HTML][HTML] Crosstalk between DNA methylation and gene expression in colorectal cancer, a potential plasma biomarker for tracing this tumor

MA Kerachian, A Javadmanesh, M Azghandi… - Scientific reports, 2020 - nature.com
Colorectal cancer (CRC), the second leading cause of cancer mortality, constitutes a
significant global health burden. An accurate, noninvasive detection method for CRC as …

[HTML][HTML] Genome-wide identification and validation of a novel methylation biomarker, SDC2, for blood-based detection of colorectal cancer

TJ Oh, N Kim, Y Moon, MS Kim, BD Hoehn… - The Journal of Molecular …, 2013 - Elsevier
Aberrant DNA methylation has shown promise as a biomarker for the early detection of
cancer. To discover novel genes frequently methylated at an early stage in colorectal cancer …

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

R Xu, W Wei, M Krawczyk, W Wang, H Luo, K Flagg… - Nature materials, 2017 - nature.com
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …

[HTML][HTML] Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification

L Liu, JM Toung, AF Jassowicz, R Vijayaraghavan… - Annals of …, 2018 - Elsevier
Background Targeted methylation sequencing of plasma cell-free DNA (cfDNA) has a
potential to expand liquid biopsies to patients with tumors without detectable oncogenic …

A multilocus blood-based assay targeting circulating tumor DNA methylation enables early detection and early relapse prediction of colorectal cancer

G Cai, M Cai, Z Feng, R Liu, L Liang, P Zhou… - …, 2021 - gastrojournal.org
Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide.
Patient survival can be greatly improved if cancerous lesions are detected early. 1 Despite a …

[HTML][HTML] LINE-1 hypomethylation status of circulating cell-free DNA in plasma as a biomarker for colorectal cancer

Y Nagai, E Sunami, Y Yamamoto, K Hata, S Okada… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a serious public health problem and non-invasive biomarkers
improving diagnosis or therapy are strongly required. Circulating cell-free DNA (cfDNA) has …