Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to
underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum …

Abstract Changes in DNA methylation with age are observed across the tree of life. The
stereotypical nature of these changes can be modeled to produce epigenetic clocks capable …

The genetic mechanisms contributing to lifespan variation remain unresolved. Based on
recent conceptual advances in our understanding of epigenetic potential and the …

Biological ageing and its mechanistic underpinnings are of immense biomedical and
ecological significance. Ageing involves the decline of diverse biological functions and …

It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …

All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

The development of 'epigenetic clocks' is changing how biomedical scientists approach age-
associated disease and leads to new insights and questions of wider significance. We …

There are numerous hallmarks of aging in mammals, but no unifying cause has been
identified. In budding yeast, aging is associated with a loss of epigenetic information that …

Research in the field of gerontology has traditionally focused on later life stages. There is
increasing evidence, however, that both the rate of age-related functional decline and the …