Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson's disease

S Zhao, L Zhang, W Ji, Y Shi, G Lai, H Chi… - Frontiers in …, 2022 - frontiersin.org
Background: Parkinson's disease (PD) is a neurodegenerative disease commonly seen in
the elderly. On the other hand, cuprotosis is a new copper-dependent type of cell death that …

[HTML][HTML] Revealing a novel contributing landscape of ferroptosis-related genes in Parkinson's disease

X Jian, G Zhao, H Chen, Y Wang, J Li, L Xie… - Computational and …, 2022 - Elsevier
Transcriptomics studies have yielded great insights into disease processes by detecting
differentially expressed genes (DEGs). In this study, due to the high heritability of …

Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease

Y Lai, C Lin, X Lin, L Wu, Y Zhao, F Lin - Frontiers in aging …, 2022 - frontiersin.org
Introduction Alzheimer's disease is the most common dementia with clinical and
pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which …

Bioinformatics analysis and prediction of Alzheimer's disease and alcohol dependence based on Ferroptosis-related genes

M Tian, J Shen, Z Qi, Y Feng, P Fang - Frontiers in aging …, 2023 - frontiersin.org
Background Alzheimer's disease (AD) is a neurodegenerative disease whose origins have
not been universally accepted. Numerous studies have demonstrated the relationship …

Immune profiling of Parkinson's disease revealed its association with a subset of infiltrating cells and signature genes

X Zhang, Z Shao, S Xu, Q Liu, C Liu, Y Luo… - Frontiers in Aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is an age-related and second most common neurodegenerative
disorder. In recent years, increasing evidence revealed that peripheral immune cells might …

Identification of immune-related hub genes in Parkinson's disease

L Chen, Y Wang, J Huang, B Hu, W Huang - Frontiers in Genetics, 2022 - frontiersin.org
Background: Parkinson's disease (PD) is a common, age-related, and progressive
neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an …

Ferroptosis-related biomarkers for Alzheimer's disease: Identification by bioinformatic analysis in hippocampus

B Wang, C Fu, Y Wei, B Xu, R Yang, C Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Globally, Alzheimer's Disease (AD) accounts for the majority of dementia,
making it a public health concern. AD treatment is limited due to the limited understanding of …

Network and pathway-based analyses of genes associated with Parkinson's disease

Y Hu, Z Pan, Y Hu, L Zhang, J Wang - Molecular neurobiology, 2017 - Springer
Parkinson's disease (PD) is a major neurodegenerative disease influenced by both genetic
and environmental factors. Although previous studies have provided insights into the …

Identification of potential immune-related hub genes in Parkinson's disease based on machine learning and development and validation of a diagnostic classification …

G Xin, J Niu, Q Tian, Y Fu, L Chen, T Yi, K Tian, X Sun… - PloS One, 2023 - journals.plos.org
Background Parkinson's disease is the second most common neurodegenerative disease in
the world. However, current diagnostic methods are still limited, and available treatments …

Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer's disease

Y Zhang, Y Miao, J Tan, F Chen, P Lei… - Journal of Translational …, 2023 - Springer
Background Alzheimer's disease (AD) is the most common neurodegenerative disease.
Mitochondrial dysfunction and immune responses are important factors in the pathogenesis …