[PDF][PDF] Hallmarks of environmental insults
Environmental insults impair human health around the world. Contaminated air, water, soil,
food, and occupational and household settings expose humans of all ages to a plethora of …
food, and occupational and household settings expose humans of all ages to a plethora of …
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
[HTML][HTML] A precision environmental health approach to prevention of human disease
Human health is determined by the interaction of our environment with the genome,
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
[HTML][HTML] From the exposome to mechanistic understanding of chemical-induced adverse effects
The exposome encompasses an individual's exposure to exogenous chemicals, as well as
endogenous chemicals that are produced or altered in response to external stressors. While …
endogenous chemicals that are produced or altered in response to external stressors. While …
The exposome and health: Where chemistry meets biology
Despite extensive evidence showing that exposure to specific chemicals can lead to
disease, current research approaches and regulatory policies fail to address the chemical …
disease, current research approaches and regulatory policies fail to address the chemical …
Environmental exposures and gene regulation in disease etiology
TM Edwards, JP Myers - Environmental health perspectives, 2007 - ehp.niehs.nih.gov
Objective Health or disease is shaped for all individuals by interactions between their genes
and environment. Exactly how the environment changes gene expression and how this can …
and environment. Exactly how the environment changes gene expression and how this can …
Oxidative stress and inflammation induced by environmental and psychological stressors: a biomarker perspective
Significance: The environment can elicit biological responses such as oxidative stress (OS)
and inflammation as a consequence of chemical, physical, or psychological changes. As …
and inflammation as a consequence of chemical, physical, or psychological changes. As …
The importance of the biological impact of exposure to the concept of the exposome
Background: The term “exposome” was originally coined in 2005 and defined as the totality
of exposures throughout the lifetime. The exposome provides an excellent scientific …
of exposures throughout the lifetime. The exposome provides an excellent scientific …
Accessing an expanded exposure science module at the comparative toxicogenomics database
CJ Grondin, AP Davis, TC Wiegers… - Environmental …, 2018 - ehp.niehs.nih.gov
The Comparative Toxicogenomics Database (CTD; http://ctdbase. org) is a free resource that
provides manually curated information on chemical, gene, phenotype, and disease …
provides manually curated information on chemical, gene, phenotype, and disease …
From the outside in: biological mechanisms linking social and environmental exposures to chronic disease and to health disparities
SP Bagby, D Martin, ST Chung… - American journal of …, 2019 - ajph.aphapublications.org
The ongoing epidemic of chronic diseases involves a spectrum of clinical entities now
understood to represent late manifestations of progressive metabolic dysfunction initiated in …
understood to represent late manifestations of progressive metabolic dysfunction initiated in …