Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic
and metabolic changes, and a proinflammatory senescence-associated secretory …

Cellular senescence is a fundamental mechanism by which cells remain metabolically
active yet cease dividing and undergo distinct phenotypic alterations, including upregulation …

Cellular senescence refers to a process induced by various types of stress that causes
irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …

Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …