A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

One of the most profound public health consequences of immune senescence is reflected in
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …

The objective of this study was to analyze the changes in the type 1 T cell response,
including the CD4+ Th1 and CD8+ T cell responses, to influenza in the elderly compared …

Influenza is a serious illness and probably the single most important cause of excess
disability and mortality during the winter months. In spite of limited efficacy in older adults …

Immunosenescence is defined as the progressive deterioration of the immune system with
aging. Immunosenescence stifles the generation of protective B and T cell-mediated …

Age-dependent changes in the cellular immune response have been mainly described in
CD8+ T cells, with relative sparing of CD4+ T cells. We show that in older compared to …

Studies of CD8 T cell responses to vaccination or infection with various pathogens in both
animal models and human subjects have revealed a markedly consistent array of age …

Aging is associated with suboptimal CD8 T cell responses to viral infections. It is not clear
whether these poor responses are due to environmental influences or quantitative and …

We investigated the relationship of memory CD4+ T cells with the evolution of influenza virus-
specific CD4+ T cell responses in healthy young and elderly people. Elderly individuals had …

Why Aging T Cells Fail: Implications for Vaccination: Immunity Skip to Main Content
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