Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and
cellular components. Advancing age closely associates with elevated markers of innate …

Inflamm-aging depicts the progressive activation of the innate immune system that
accompanies human aging. Its role as a disease-predisposing condition has been …

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors
that induce inflammation are not well understood. We previously identified a cell …

Persistent DNA lesions build up with aging triggering inflammation, the body's first line of
immune defense strategy against foreign pathogens and irritants. Once established, DNA …

Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Highlights•Cellular senescence is a key cellular stress response pathway.•Senescent cells
produce various bioactive factors referred to collectively as the SASP.•The cGAS-STING …

Senescence of the immune system is characterized by a state of chronic, subclinical, low-
grade inflammation termed 'inflammaging', with increased levels of proinflammatory …

Adult stem cells ensure tissue homeostasis and regeneration after injury. Due to their
longevity and functional requirements, throughout their life stem cells are subject to a …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …