Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Epigenetics, a combination of DNA modifications, chromatin organization, and variations in
its associated proteins, configure a new entity that regulates gene expression throughout …

Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a
condensed state linked to transcriptional repression (heterochromatin). These states are …

Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape,
including progressive loss of DNA methylation over gene-poor genomic regions (,). Global …

There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

DNA methylation is known to be abnormal in all forms of cancer, but it is not really
understood how this occurs and what is its role in tumorigenesis. In this review, we take a …

Epigenetic regulation of gene expression is a dynamic and reversible process with DNA
methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …